● What is urolixin A
Urolithin A (abbreviated as UA) is a natural polyphenol compound produced by intestinal microbiota metabolism of ellagitannins. Ellagitannins are widely found in foods such as pomegranates, strawberries, raspberries, walnuts, and red wine. When people consume these foods, the ellagitannins are converted into urolithin A by specific microbial populations in the intestine.
● Basic properties of urolithin A
English name: Urolithin A
CAS number: 1143-70-0
Molecular form. : C₁₃H₈O₄
Molecular weight: 228.2
Appearance: Yellow or light yellow solid powder
● Bioactivity and efficacy of urolixin A
1:Anti-aging effect
Enhance mitochondrial function: urolithin A can stimulate mitophagy, help clear damaged mitochondria, promote the generation of new, functional mitochondria, so as to maintain energy metabolism of cells and delay the aging process.Prolonging cell life: By improving the functional state of cells and increasing cell vitality, urolixin A helps to extend the life of cells.
2:Neuroprotective effect
Reduce neuroinflammation: Urolitin A can cross the blood-brain barrier, reduce amyloid beta (Aβ) and tau protein lesions, and induce mitochondrial autophagy, thereby improving symptoms of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.Improved memory function: Studies have shown that urolixin A can significantly improve learning, memory and olfactory function in model mice.
3:Muscular protection
Increase muscle strength and endurance: Urolixin A can improve muscle health, increase muscle strength and endurance, and has a potential intervention role in muscular dystrophy related diseases.Promotes muscle recovery: By regulating mechanisms such as mitochondrial function within muscle cells, urolixin A helps the elderly or people with mobility difficulties due to disease to perform the required exercise and promote muscle recovery.
4:Anti-inflammatory effect
Inhibition of inflammatory factors: urolithin A can inhibit the production and release of inflammatory factors such as IL-6 and TNF-α, and reduce inflammatory response.Regulation of inflammatory signaling pathways: By inhibiting the activation of NF-κB, MAPK and other inflammatory signaling pathways, urolitin A further reduces inflammatory response.
5:antioxidation
Scavenging free radicals: Urolixin A has the ability to directly remove free radicals and reduce the damage of oxidative stress on cells.Enhance antioxidant defense: Urolixin A can enhance the endogenous antioxidant defense ability of cells by activating the Nrf2 antioxidant pathway and up-regulating the expression of various antioxidant enzymes such as glutathione peroxidase and superoxide dismutase.
6:Antitumor effect
Inhibition of tumor cell proliferation: urolixin A can inhibit the proliferation, invasion and metastasis of prostate cancer, colon cancer and other tumor cells.Induction of tumor cell apoptosis: By activating apoptosis-related signaling pathways, urolixin A can induce tumor cell apoptosis, thereby inhibiting tumor growth.
7:Improve metabolic diseases
Regulation of blood sugar and blood lipid: urolithin A can regulate the body's metabolic pathway and play a positive role in improving blood sugar and blood lipid levels.Anti-obesity: By inducing brown fat activation and white fat Browning, urolixin A can accelerate fat catabolism and prevent fat accumulation caused by diet.
8:Improve kidney disease
Reducing kidney injury: Urolixin A can reduce kidney injury by activating mitochondrial autophagy of kidney cells, alleviating collagen accumulation, reducing fibrocyte proliferation or reducing fiber tissue deposition to slow down the development of fibrosis process.
● Application prospect of urolithin A
1:Drug research and development
Urolixin A is a popular target for anti-aging, neuroprotective, anti-tumor drug development due to its diverse biological activities.At present, A number of research institutions and enterprises have begun to study the drug development of urolixin A, hoping to develop efficient and safe drugs.
2:Cosmetics research and development
The antioxidant and anti-inflammatory effects of urolixin A make it have broad application prospects in the field of cosmetics.By adding urolixin A, cosmetics can enhance anti-aging effects and improve skin condition.
3:Food research and development
Urolixin A has potential application value in food field because of its various biological functions.By adding ellagitannin-rich foods or urolithin A supplements, foods can enhance health benefits and meet consumer demand for healthy foods.
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Post time: Mar-27-2025