In the journey of pursuing health and delaying aging, scientific research constantly brings us new hopes and possibilities. In recent years, NMN (Nicotinamide Mononucleotide), a highly regarded bioactive substance, has gradually come into the public eye and attracted widespread attention. What exactly is it? And why has it set off such a craze in the health field? Let’s delve into the mysteries of NMN together.
●What is NMN?
NMN, namely Nicotinamide Mononucleotide, is a molecule that naturally exists in all forms of life. In the human body, NMN is a key precursor for the synthesis of coenzyme I (NAD+). Coenzyme I (NAD+) participates in numerous important metabolic reactions within cells and plays a crucial role in maintaining the normal functions and vitality of cells. As people age, the level of NAD+ in the human body gradually decreases, which is believed to be closely related to many physiological changes associated with aging and the occurrence and development of diseases. Supplementing with NMN can effectively increase the content of NAD+ in the body, thus providing sufficient energy support for the normal operation of cells and helping to maintain the body’s youthful state.
●The working principle of NMN
The mechanism of action of NMN mainly revolves around its elevation of NAD+ levels. When we ingest NMN, it is rapidly absorbed by the body and converted into NAD+ under the action of a series of enzymes. As a coenzyme for many key enzymes, NAD+ participates in important physiological processes within cells, such as energy metabolism, DNA repair, and gene expression regulation. In terms of energy metabolism, NAD+ is involved in the process of cellular respiration, helping mitochondria convert nutrients into ATP, an energy molecule that cells can directly utilize. Sufficient NAD+ levels contribute to improving the function and efficiency of mitochondria, providing more energy for cells and enabling us to have more abundant energy and vitality. In the aspect of DNA repair, NAD+ is an important substrate for the PARP (Poly ADP – Ribose Polymerase) family. When cells are damaged by ultraviolet rays, oxidative stress, etc., PARP enzymes are activated and use NAD+ to synthesize PAR (Poly ADP – Ribose), and then recruit related proteins to repair the damaged DNA. Maintaining a high level of NAD+ can enhance the activity of PARP enzymes, accelerate the DNA repair process, reduce the accumulation of gene mutations and cell damage, and help prevent the occurrence of aging – related diseases. In addition, NAD+ is also involved in the regulation of the Sirtuins protein family. Sirtuins proteins play important roles in cell aging, metabolic regulation, inflammatory responses, etc. As a coenzyme of Sirtuins, NAD+ can activate Sirtuins proteins, regulate gene expression, and affect the physiological functions and lifespan of cells. By supplementing NMN to increase NAD+ levels, it can indirectly activate Sirtuins proteins and exert functions such as delaying cell aging and improving metabolic function.
●The Efficacy of NMN
1：Delaying senescence
The process of aging is accompanied by the gradual decline of the functions of various organs and systems in the body. NMN delays the aging process at the cellular level through multiple pathways such as increasing NAD+ levels, improving mitochondrial function, enhancing DNA repair ability, and activating Sirtuins proteins. Research shows that supplementing with NMN can significantly improve the physical functions of experimental animals, such as enhancing muscle strength, improving exercise endurance, and enhancing cognitive function, making them appear and behave in a younger state. For humans, long-term supplementation with NMN is also expected to delay skin aging, reduce the appearance of wrinkles and age spots, improve sleep quality, and enhance the overall health level of the body, allowing us to maintain elegance and vitality .
2：Boost immunity
NMN has a positive regulatory effect on the immune system. On the one hand, it can promote the proliferation and differentiation of immune cells, enhance the activity of immune cells, and improve the body’s immune response ability. On the other hand, NMN helps maintain the normal function of mitochondria in immune cells, providing sufficient energy support for the activities of immune cells. By supplementing with NMN, we can enhance our own immunity, reduce the risk of illness, and better cope with the challenges of the external environment.
3：Improve metabolic function
Metabolic dysfunction is the root cause of many chronic diseases, such as obesity, diabetes, cardiovascular diseases, and so on. NMN can improve metabolic function by regulating the metabolic pathways within cells. Research has found that supplementing with NMN can enhance insulin sensitivity, promote the uptake and utilization of glucose, and help maintain blood sugar stability. At the same time, NMN can also boost fat metabolism, reduce the accumulation of fat in the body, and play a positive role in preventing and improving obesity. In addition, NMN has a protective effect on the cardiovascular system. It can lower blood lipid levels, improve vascular endothelial function, and reduce the risk of cardiovascular diseases. For those who are concerned about metabolic health, NMN is undoubtedly a nutritional supplement with potential value.
4：Improve cognitive function
With the growth of age, brain function gradually declines, memory decline, cognitive disorders and other problems increasingly troubled the elderly. NMN has shown promising results in improving cognitive function.
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Post time: Mar-29-2025