Powered by Xi’an Rainbow Bio-Tech Co.,Ltd, a Leading Phytochemical Innovator
1. Introduction to Isoquercetin
Isoquercetin (CAS No. 482-35-9), a flavonol glycoside derived from quercetin, is a naturally occurring polyphenolic compound found in various plants, including onions, apples, buckwheat, and medicinal herbs like Ginkgo biloba and Hippophae rhamnoides. As a key bioactive ingredient, it has gained significant attention in the pharmaceutical, nutraceutical, food, and cosmetic industries due to its robust antioxidant, anti-inflammatory, and therapeutic properties. This document provides a comprehensive overview of isoquercetin, including its chemical structure, quality standards, diverse applications, and the technological expertise of [Your Company Name] in delivering premium isoquercetin solutions.
2. Basic Characteristics of Isoquercetin
2.1 Chemical Structure and Properties
●Molecular Formula: C₂₁H₂₀O₁₁
●Molecular Weight: 464.38 g/mol
●Chemical Structure: A flavonol aglycone (quercetin) linked to a glucose molecule via a glycosidic bond (3-O-glucoside).
●Physical Appearance: Yellowish crystalline powder with a bitter taste.
●Solubility: Sparingly soluble in water; soluble in ethanol, methanol, and DMSO.
●Stability: Sensitive to light and heat; stable under controlled storage conditions (2-8°C).
2.2 Natural Sources
Isoquercetin is abundantly present in:
●Plants: Buckwheat (Fagopyrum esculentum), onions (Allium cepa), apples (Malus domestica), and berries (e.g., blueberries, cranberries).
●Medicinal Herbs: Ginkgo biloba (leaves), Hypericum perforatum (St. John’s Wort), and Sophora japonica (Japanese pagoda tree).
●Foods: Green tea, red wine, and certain types of honey.
2.3 Bioactivity and Mechanisms of Action
●Antioxidant Activity: Scavenges free radicals (e.g., hydroxyl, superoxide) and inhibits oxidative stress via upregulation of Nrf2 signaling.
●Anti-Inflammatory: Suppresses pro-inflammatory cytokines (TNF-α, IL-6) and inhibits NF-κB pathway activation.
●Cardioprotective: Improves endothelial function, reduces blood pressure, and inhibits platelet aggregation.
●Anticancer: Induces apoptosis in cancer cells (e.g., breast, lung, colorectal) and inhibits angiogenesis.
●Neuroprotective: Protects against neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) by reducing oxidative damage and inflammation.
3. Product Quality: Premium-Grade Isoquercetin by Xi’an Rainbow Bio-Tech CO.,Ltd
3.1 Purity and Formulation Standards
●Purity: ≥98% (HPLC assay, USP/EP/BP compliant).
●Heavy Metals: ≤10 ppm (ICP-MS tested).
●Microbiological Safety: Compliant with USP <61> and <62> (total plate count ≤1000 CFU/g, yeast/mold ≤100 CFU/g, no E. coli or Salmonella).
●Solvent Residues: ≤0.5% (ethanol, methanol; GC-MS tested).
3.2 Production Process
Xi’an Rainbow Bio-Tech Co.,Ltd employs a proprietary, eco-friendly extraction and purification process:
1.Raw Material Sourcing: Premium-grade plant extracts from wild materials.
2.Extraction: Ultrasound-assisted extraction (UAE) with food-grade solvents (ethanol/water).
3.Purification: Column chromatography (silica gel/ODS) and preparative HPLC for high-purity isolation.
4.Formulation: Spray-drying or freeze-drying to produce fine powders or granules with tailored particle sizes (10-100 μm).
3.3 Quality Control (QC) System
●State-of-the-Art Laboratories: Equipped with HPLC, LC-MS, NMR, and GC-MS for rigorous testing.
●Batch Traceability: Full documentation from raw material to final product (ISO 22000:2018 compliant).
●Certifications: Kosher, Halal, and FSSC22000 certifications.
4. Applications of Isoquercetin
4.1 Pharmaceutical Industry
●Drug Development:
●Anticancer Agents: Formulated in combination therapies (e.g., with cisplatin) to enhance cytotoxicity and reduce side effects.
●Cardiovascular Drugs: Used in antihypertensive and anticoagulant formulations (e.g., coenzyme Q10 + isoquercetin tablets).
●Neuroprotective Drugs: Incorporated into Alzheimer’s treatment prototypes (e.g., donepezil + isoquercetin capsules).
4.2 Nutraceutical and Dietary Supplements
●Health Benefits:
●Immune support, anti-aging, and metabolic regulation (e.g., blood glucose management).
●Joint health (reduces osteoarthritis inflammation).
●Market Products:
●Capsules (200-500 mg isoquercetin/day).
●Functional beverages (e.g., isoquercetin-infused green tea).
4.3 Food and Beverage Industry
●Functional Ingredients:
●Natural preservative (extends shelf life via antimicrobial activity).
●Nutritional fortification (antioxidant enrichment in juices, snacks).
4.4 Cosmetics and Personal Care
●Skin Health:
●Antioxidant protection against UV damage.
●Anti-aging (collagen synthesis promotion, wrinkle reduction).
●Anti-inflammatory for sensitive skin (e.g., eczema, rosacea).
●Formulations:
●Serums, creams, and masks (0.5-2% isoquercetin).
4.5 Veterinary Medicine
●Animal Health:
●Anti-inflammatory for pets (e.g., osteoarthritis in dogs).
●Immune support in livestock (reduces stress-related oxidative damage).
5. Xi’an Rainbow Bio-Tech Co.,Ltd – Your Trusted Partner in Phytochemical Innovation
5.1 Company Overview
Founded in2010, Xi’an Rainbow Bio-Tech Co.,Ltd is a global leader in the research, development, and production of plant-based bioactives. With a 20,000 m² GMP-certified facility and a team of 150+ scientists, we specialize in:
●Customized extraction and purification of flavonoids, alkaloids, and polyphenols.
●Contract manufacturing (CMO) for pharmaceutical and nutraceutical clients.
●Proprietary formulations (e.g., nanoencapsulated isoquercetin for enhanced bioavailability).
5.2 R&D Capabilities
●Collaborations: Partnerships with leading universities (e.g., Shaanxi Normal University ) and research institutes.
●Patents: 12+ patents on isoquercetin extraction, formulation, and applications.
5.3 Production Excellence
●Capacity: 10 metric tons/year of isoquercetin (95-99% purity).
●Sustainability: Zero-waste production via closed-loop solvent recycling.
●Global Reach: Served 200+ clients in 30+ countries (e.g., USA, EU, Japan, Australia).
5.4 Client-Centric Services
●Technical Support: Customized dossier preparation (e.g., DMF, CEP).
●Regulatory Compliance: Full support for FDA, EFSA, and TGA submissions.
●Packaging Options: Custom packaging (aluminum foil bags, HDPE drums) with moisture/light protection.
6. Conclusion: Isoquercetin – A Natural Solution for Modern Challenges
Isoquercetin’s versatile bioactivity positions it as a cornerstone ingredient in healthcare, nutrition, and personal care. Xi’an Rainbow Bio-Tech Co.,Ltd commitment to quality, innovation, and sustainability ensures that our isoquercetin products meet the highest global standards. Whether for drug development, dietary supplements, or cosmetic formulations, our solutions empower industries to harness nature’s potential for healthier lives.
Join hands with Xi’an Rainbow Bio-Tech Co.,Ltd – where science meets nature.
Post time: Apr-01-2025